Regenerative medicine

Cell therapy is a branch of reconstructive medicine in which viable cells are injected into a patient to heal and regenerate injured tissues and whole organs. The history of this therapy can perhaps be traced to more than two hundred years ago, when red blood cells were injected to repair the blood tissue. Cells are sometimes cultured or isolated before injection.
Any treatment in the medical sciences must go through very specific stages before they can be approved for use in patients. The stages include initial tests in the laboratory, animal study and clinical trials (performed to ensure safety and efficiency.) In the animal study stage, side effects and therapeutic mechanisms are examined so that deeply sufficient knowledge makes way for clinical trials.
Clinical trials involve 3 phases prior to market entry and one after introduction to market. First, the safety of therapy is evaluated in a limited population. In next steps, researcher finds out about how safe the therapy is and how well it works in the control group.
Then, the therapy is compared with existing therapies, medicine or both. If the results demonstrate operatively therapeutic effects, it receives initial certificates of qualification from health regulatory organizations in Iran, mainly the Ministry of Health and Medical Education. Conducting a market survey as a last phase will herald the wide use of the therapy for patients.
Cell Therapy Center of Royan Institute provides the medical services which their efficacy, effectiveness and efficiency have already been evaluated in other research centers around the world or in Royan Institute. The Cell Therapy services will be fully explained to patients if the licensing procedure of services are not yet approved by the Ministry of Health and Medical Education.

Medical services of Royan Cell Therapy, it is concerned with are the ones stated as follows:

Vitiligo

Vitiligo

Melanocyte cell injection for patients with vitiligo Vitiligo is a pigmentation disorder in which white patches of skin appear on different parts of the body. Histologically it is characterized by absence of melanocytes along the epidermal basal layer.
In this treatment, the melanocyte cells are first separated from the individual’s own skin sample under completely sterile conditions and transplanted intradermally. The results of this new treatment for patients with blemishes have been completely safe and satisfactory. Ultraviolet light may be used in conjunction with cell transplantation.
Details of candidate patients for cell therapy:
• Age> 12 years
• Disease stability ≥ 12 months

Knee Osteoarthritis

Knee Osteoarthritis

Osteoarthritis is the most common degenerative disease of joint cartilage and the underlying bone, in middle age onward. It causes pain and stiffness, especially in the hip, knee, and thumb joints. knee osteoarthritis is the most common form of arthritis. Treatments involve high costs in terms of social and economic, are palliative and do not contemplate healing by regenerative therapy. It has been shown recently, that mesenchymal stem cells (MSC) can be expanded in vitro and may regenerate several damaged or injured tissues. In addition, it has demonstrated that MSC are able to modulate immune responses and to control inflammation through its action on T lymphocytes.
Details of candidate patients for cell therapy:
• Age 18 to 65
• Established osteoarthritis of knee
• Any uncontrolled chronic or acute diseases

Fibroblast Scar

Fibroblast Scar

Culture and transplantation of mesenchymal fibroblasts in the treatment of scars caused by burns, surgery and acne This treatment is mainly offered to patients who have acne scars, surgery and burns on their skin. In this treatment, cells obtained from the patient’s own skin biopsy are cultured in a laboratory and injected into them three times.
Details of candidate patients for cell therapy:
• Mild to severe acne scars
• 18 Age 65 years old